Eric Wilke graduated from Texas A&M University in 1991 and then attended Texas A&M College of Medicine. After medical school, he completed a four-year Emergency Medicine residency at Maricopa Medical Center in Phoenix, Arizona. After completing residency, Dr. Wilke continued at Maricopa Medical Center as teaching faculty and medical director. At the same time, he and his partners started a medical software company that grew and merged into a major company in the space of electronic data capture in FDA pharmaceutical trials (currently DataTrak). Dr. Wilke and his partners launched Affilion, Inc. for the management and staffing of Emergency Departments. Currently, he is the Chief Medical Officer of Affilion and oversees seven different emergency departments across the Southwest. Dr. Wilke additionally works clinically at College Station Medical Center where is also the Emergency Department Medical Director and is serving a term as hospital Chief of Staff. Dr. Wilke is active in EMS. He is the medical director for the College Station Fire Department along with the Blinn and TEEX paramedic training programs. He is involved in teaching medical students and Family Medicine residents at the Texas A&M Health Science Center.

Dr. Wilke has been married to Julie for 18 years and has two children. He enjoys camping and hiking, and has organized several medical mission trips to Africa.